If you have a powerful computer you should have no problem with using enhanced AA to compenstate. LumaSharpen seems like a great idea, who doesn't want sharper textures? However, it does come at a cost, as you will have to value either slightly sharper textures or a decreased Anti-Aliasing effect. Vibrance will make every colour in the game either more or less pronounced (this setting is probably the most personal, as I prefer realistic or bright-looking colours, while most others opt for a more washed-out look). Bloom makes lights look more realistic, and Curves can make dark areas even darker. I usually enable Bloom, Vibrance and Curves for all games.
You can change shortcuts by clicking the Injector Settings button (see last screenshot). By default, Print Screen will save a screenshot in bmp format with the SweetFX setting to your game directory. You can press Scroll Lock (default key) to turn it on and off to see how much has changed (or take comparison screenshots). Simply use (and don't forget to save) the configurator like normal, and press Pause (default key) to refresh. SweetFX is absolutely brilliant for editing as you can edit the settings while in-game.
